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Lumpy protein domains wrap around a strand of guide RNA in this CRISPR Cas9 model, gripping a length of double stranded DNA that spirals out below. The clustered globular surface contrasts with the smooth looping RNA threaded through the center and the twisted ladder of the DNA helix with its base pairs. The open structure shows how the molecule holds its target. A standout teaching model for a biology or genetics classroom, a lab desk or a science talk about gene editing.

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